UNC3133 (Compound 16) is a selective and orally active macrocyclic mer tyrosine kinase (MerTK) inhibitor with an IC50 of 8.1 nM. UNC3133 has certain selectivity towards the TAM family (Axl and Tyro3) (with a selectivity of approximately 7 times for Axl and about 10 times for Tyro3), and has similar inhibitory activity towards Flt3. UNC3133 exhibits anti-tumor and anti-infection activities[1].
Molekulargewicht:
504.71
CAS Nummer:
[2011034-35-6]
Formel:
C30H44N6O
Target-Kategorie:
TAM Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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