Aurora kinase-IN-1 (Compound 9) is a potent inhibitor of aurora kinase. Aurora kinase-IN-1 upregulates the expression of G1 cell cycle inhibitory proteins including p21 and p27, and G1 progressive cyclin D1, and downregulates G1-to-S progressive cyclins, resulting in cell cycle arrest at the G1/S boundary. Aurora kinase-IN-1 also induces apoptosis. Aurora kinase-IN-1 is a lead compound for chemotherapeutic agents[1].
Molekulargewicht:
667.34
Formel:
C30H25Br2N3O5
Target-Kategorie:
Apoptosis,Aurora Kinase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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