PU-11 is a Hsp90alpha/Hsp90beta inhibitor with IC50 values of 18.6 µM and 89.8 µM and Kd values of 2 and 4.2 µM. PU-11 binds to the ATP-binding pocket of Hsp90alpha and Hsp90beta and displays selective binding preference for Hsp90alpha over Hsp90beta, mediated by the nonconserved Hsp90alpha Ser52 residue. PU-11 can be used for the research of neurodegenerative disorders[1].
Molekulargewicht:
369.43
CAS Nummer:
[1454619-18-1]
Formel:
C19H23N5O3
Target-Kategorie:
HSP
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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