Metopimazine (EXP999, RP9965) is a phenothiazine, orally available, selective dopamine D2 receptor antagonist that does not penetrate the blood-brain barrier. Metopimazine blocks dopamine D2 receptors in the chemoreceptor trigger zone and the periphery, thereby inhibiting nausea and vomiting. Metopimazine is indicated for chemotherapy-induced nausea and vomiting, and has low central side effects due to its poor brain penetration. The use of metopimazine in acute gastroenteritis may have potential risks[1][2][3].
Molekulargewicht:
445.60
Reinheit:
99.75
CAS Nummer:
[14008-44-7]
Formel:
C22H27N3O3S2
Target-Kategorie:
Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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