()12-HEPE is produced by non-enzymatic oxidation of EPA. It contains equal amounts of 12(S)-HEPE and 12(R)-HEPE. The biological activity of ()12-HEPE is likely mediated by one of the individual isomers, most commonly the 12(S) isomer in mammalian systems. 12-HEPE inhibits platelet aggregation with the same potency as 12-HETE, exhibiting IC50 values of 24 and 25 µM, respectively.1 These compounds are also equipotent as inhibitors of U46619-induced contraction of rat aorta (IC50s=8.6-8.8 µM).
Molekulargewicht:
318.45
CAS Nummer:
[81187-21-5]
Formel:
C20H30O3
Target-Kategorie:
Prostaglandin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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