YM-202074 is a selective, allosteric metabotropic glutamate receptor type 1 (mGluR1) antagonist with high affinity. YM-202074 binds to the allosteric site of rat mGluR1 with a Ki of 4.8 nM. YM-202074 fumarate also inhibits mGluR1-mediated inositol phosphate production in rat cerebellar granule cells with an IC50 of 8.6 nM. YM-202074 has potent neuroprotective effects in transient MCA (tMCA) occlusion rat models[1].
Molekulargewicht:
414.56
CAS Nummer:
[299900-83-7]
Formel:
C22H30N4O2S
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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