KSC-34, a covalent modifier of protein disulfide isomerase A1 (PDIA1), is also a selective and potent a-site inhibitor of PDIA1 with an IC50 of 3.5 µM. KSC-34 displays a 30-fold selectivity for a domain over a' domain and displays high selectivity for PDIA1 in complex proteomes with minimal engagement of other members of the PDI family[1]. KSC-34 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
429.95
Reinheit:
99.94
CAS Nummer:
[2226201-97-2]
Formel:
C21H28ClN7O
Target-Kategorie:
PDI
Anwendungsbeschreibung:
MCE Product type: Reference compound
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