PNR-7-02 inhibits Pol eta function with an IC50 value of near 8 µM, which binds to the little finger domain. PNR-7-02 is also an inhibitor against hRev1 and hpol lambda (lambda). PNR-7-02 acts synergistically with Cisplatin (HY-17394) to kill chronic myeloid leukaemia and ovarian cancer cell lines. PNR-7-02 is an indole thio-barbituric acid (ITBA) derivative with both N-napthoyl moiety and 5-chloro substituent on the indole ring[1][2].
Molekulargewicht:
445.92
Reinheit:
98
CAS Nummer:
[1633660-76-0]
Formel:
C24H16ClN3O2S
Target-Kategorie:
Reverse Transcriptase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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