MK-8825 is an orally active, selective CGRP receptor antagonist with a Ki value of 47 pM for human CGRP receptors and 17 nM for rat CGRP receptors. MK-8825 blocks CGRP-stimulated cAMP responses and exhibits competitive-like antagonism. MK-8825 can be used in the research of migraine and temporomandibular joint disorders[1][2].
Molekulargewicht:
572.61
CAS Nummer:
[1380887-60-4]
Formel:
C31H30F2N6O3
Target-Kategorie:
CGRP Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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