DO34 is a selective DAGL inhibitor, with an IC50 of 6 nM for DAGLalpha conversion of SAG to 2-AG. DO34 blocks de novo 2-AG synthesis, and suppresses tonic CB1 receptor activation. DO34 blocks depolarization-induced suppression of excitation and inhibition in the cerebellum and hippocampus. DO34 regulates feeding behavior and locomotor activity in mice. DO34 abolishes AM251-mediated enhancement of parallel fiber-evoked excitatory postsynaptic currents in cerebellar slices from MAGL global knockout mice. DO34 can be used for the research of energy balance disorder and neuroinflammation[1][2][3].
Molekulargewicht:
531.53
Reinheit:
99.30
CAS Nummer:
[1848233-58-8]
Formel:
C26H28F3N5O4
Target-Kategorie:
DAGL
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
