CJ-15208 is a potent and selective kappa-opioid receptor antagonist with significant opioid activity. CJ-15208 exhibited strong analgesic effects in the warm water tail withdrawal test in mice and was mediated through multiple opioid receptors. The stereoisomers of CJ-15208 exhibited different opioid activity characteristics, for example, one stereoisomer exhibited kappa-opioid receptor antagonism, while the other exhibited delta-opioid receptor antagonism. All stereoisomers of CJ-15208 had no significant effects on respiration. The stereoisomers of CJ-15208 did not lead to the development of drug tolerance, which makes it potential in the further development of safe opioid analgesics[1].
Molekulargewicht:
577.67
CAS Nummer:
[210236-47-8]
Formel:
C34H35N5O4
Target-Kategorie:
Opioid Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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