YM928 is an orally active and noncompetitive alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist. YM928 inhibits AMPA receptor-mediated toxicity in primary rat hippocampal cultures with an IC50 value of 2 µM. YM928 blocks AMPA-induced intracellular calcium influx with an IC50 value of 3 µM and antagonizes AMPA-induced inward currents with an IC50 value of 1 µM. YM928 is promising for research of neurological disorders[1].
Molekulargewicht:
303.77
CAS Nummer:
[190842-36-5]
Formel:
C14H10ClN3OS
Target-Kategorie:
iGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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