12-Oxo phytodienoic acid (90%) (12-OPDA (90%)) is a plant lipid-derived anti-inflammatory compound. 12-Oxo phytodienoic acid (90%) induces the expression of SOCS-1 and inhibits LPS (HY-D1056)-induced activation of the NF-kappaB and p38 MAPK signaling pathways. 12-Oxo phytodienoic acid (90%) inhibits LPS-induced expression of IL-6 and TNF-alpha, and reduces LPS-induced NO production by decreasing iNOS levels. 12-Oxo phytodienoic acid (90%) induces activation of the Nrf2 signaling cascade. 12-Oxo phytodienoic acid (90%) can be used for the research of neurodegenerative diseases[1].
