GSK 366 is a type II kynurenine-3-monooxygenase (KMO) inhibitor with IC50 values of 2.3 nM and 0.7 nM for human KMO and P. fluorescens-KMO (Pf-KMO). GSK 366 binds to KMOs substrate site, prevents productive NADPH association, substrate binding, and FAD hydroperoxy species formation. GSK 366 does not stimulate hydrogen peroxide (H2O2) production and reduces H2O2 levels. GSK 366 can be used for the researches of inflammation and neurological disease, such as acute pancreatitis multiple organ dysfunction syndrome and Alzheimers disease[1].
Molekulargewicht:
361.78
Reinheit:
99.80
CAS Nummer:
[1953157-39-5]
Formel:
C17H16ClN3O4
Target-Kategorie:
Others
Anwendungsbeschreibung:
MCE Product type: Reference compound
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