ABT-866 is an alpha1A-adrenoceptor agonist and an antagonist at the alpha1B- and alpha1D-adrenoceptor subtypes. ABT-866 has an EC50 of 0.60 µM for the alpha1A in the rabbit urethra. ABT-866 has a pA2 value of 5.4 for the alpha1B in the rat spleen. ABT-866 has a pA2 value of 6.2 for the alpha1D in the rat aorta. ABT-866 exhibits good urethral selectivity and lower cardiovascular side effects in stress urinary incontinence models. ABT-866 can be used for the research of diseases such as stress urinary incontinence[1][2].
Molekulargewicht:
265.33
CAS Nummer:
[258526-74-8]
Formel:
C12H15N3O2S
Target-Kategorie:
Adrenergic Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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