Conglobatin (FW-04-806), a macrolide dilactone, is isolated from the culture of Streptomyces conglobatus. Conglobatin is an orally active Hsp90 inhibitor. Conglobatin can bind to the N-terminal domain of Hsp90 and disrupt Hsp90-Cdc37 complex formation. Conglobatin induces apoptosis in human breast cancer cells and esophageal squamous cell carcinoma cells, and exhibits antitumor activity in vivo[1][2][3].
Molekulargewicht:
498.61
Reinheit:
95.48
CAS Nummer:
[72263-05-9]
Formel:
C28H38N2O6
Target-Kategorie:
Apoptosis,HSP
Anwendungsbeschreibung:
MCE Product type: Natural Products
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