(rel)-AR234960, CAS [[1408311-94-3]]

Produktübersicht

• Artikelname: (rel)-AR234960, CAS [[1408311-94-3]]
• Artikelnummer: MCE-HY-120006A
• Hersteller Artikelnummer: HY-120006A
• Alternativnummer: MCE-HY-120006A-50MG,MCE-HY-120006A-10MMX1ML,MCE-HY-120006A-5MG,MCE-HY-120006A-10MG,MCE-HY-120006A-100MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(rel)-AR234960 is a selective and competitive agonist of the G protein-coupled receptor MAS. (rel)-AR234960 binds to the MAS receptor to activate the downstream ERK1/2 signaling pathway, inducing the expression of connective tissue growth factor (CTGF) and its downstream collagen subtype genes (such as COL1A1, COL3A1). (rel)-AR234960 promotes collagen synthesis in cardiac fibroblasts through the MAS-ERK1/2-CTGF pathway and aggravates extracellular matrix remodeling. (rel)-AR234960s in vitro effect can be blocked by the MAS inverse agonist AR244555 and MEK1 inhibitor. (rel)-AR234960 regulates the expression of cardiac fibrosis-related genes and can be used in the study of heart failure[1][2].

Produkteigenschaften

• Molekulargewicht: 555.62
• Reinheit: 98.95
• CAS Nummer: [1408311-94-3]
• Formel: C27H30FN5O5S
• Target-Kategorie: ERK

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound