LP-922761 hydrate is a potent, selective and orally active adapter protein-2 associated kinase 1 (AAK1) inhibitor with IC50s of 4.8 nM and 7.6 nM in enzyme and cell assays, respectively. LP-922761 hydrate also inhibits BMP-2-inducible protein kinase (BIKE) with an IC50 of 24 nM. LP-922761 hydrate shows less activity at cyclin G-associated kinase (GAK), opioid, adrenergic alpha2 or GABAa receptors[1].
Molekulargewicht:
414.98
Reinheit:
98
Formel:
C21H26N6O3.1/4H2O
Target-Kategorie:
AAK1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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