(2Z,3Z)-U0126, CAS [[218601-62-8]] Preis auf Anfrage
Artikelnummer:
MCE-HY-12031B
Hersteller Artikelnummer:
HY-12031B
Alternativnummer:
MCE-HY-12031B-1UNIT
Hersteller:
MedchemExpress
Kategorie:
Biochemikalien
(2Z,3Z)-U0126 is a selective inhibitor of MEK1 and MEK2, demonstrating potent antiinflammatory effects by noncompetitively inhibiting AP-1 transcriptional activity with IC50 values of 72 nM for MEK1 and 58 nM for MEK2. (2Z,3Z)-U0126 also inhibits anchorage-independent growth of Ki-ras-transformed rat fibroblasts by blocking both the extracellular signal-regulated kinase and mammalian target of rapamycin pathways. Additionally, (2Z,3Z)-U0126 can undergo isomerization and cyclization, resulting in various products that show reduced affinity for MEK and diminished AP-1 inhibition compared to the parent compound.
Molekulargewicht:
380.49
CAS Nummer:
[218601-62-8]
Formel:
C18H16N6S2
Target-Kategorie:
Others
Anwendungsbeschreibung:
MCE Product type: Reference compound
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