Clofutriben (ASP3662) is a selective, orally active and brain-penetrant 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1) inhibitor with Ki values of 5.3 nM (human), 2.6 nM (mouse), and 23 nM (rat). Clofutriben inhibits conversion of inactive glucocorticoids to active glucocorticoids, reducing intracellular glucocorticoid exposure. Clofutriben ameliorates neuropathic pain, and restores muscle pressure thresholds in rodent models, while lacking effects in inflammatory pain[1][2].
Molekulargewicht:
424.80
CAS Nummer:
[1204178-50-6]
Formel:
C19H16ClF3N4O2
Target-Kategorie:
11beta-HSD
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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