VU0360172 is a potent and selective mGlu5 receptor positive allosteric modulator with an EC50 value of 16 nM and a Ki of 195 nM, respectively. VU0360172 stimulates polyphosphoinositide (PI) hydrolysis in vivo, which is abrogated in mGlu5 receptors gene deleted mice[1]. VU0360172 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Molekulargewicht:
294.32
Reinheit:
98.07
CAS Nummer:
[1310012-12-4]
Formel:
C18H15FN2O
Target-Kategorie:
mGluR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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