TP-004 is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM against MetAP2. TP-004 is a chemical probe. TP-004 suppresses MetAP2 enzymatic activity, blocks N-terminal methionine cleavage, impairs protein maturation and stability, and thereby inhibits cell proliferation and angiogenesis. TP-004 can be used for the study of tumors and diseases associated with excessive angiogenesis[1].
Molekulargewicht:
363.34
Reinheit:
99.17
CAS Nummer:
[1454299-21-8]
Formel:
C17H16F3N5O
Target-Kategorie:
MetAP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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