(R)-MRT199665

Produktübersicht

• Artikelname: (R)-MRT199665
• Artikelnummer: MCE-HY-120877A
• Hersteller Artikelnummer: HY-120877A
• Alternativnummer: MCE-HY-120877A-10MG,MCE-HY-120877A-1MG,MCE-HY-120877A-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

(R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKalpha1/AMPKalpha2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370[1][2][3].

Produkteigenschaften

• Molekulargewicht: 469.58
• Reinheit: 98.70
• Formel: C28H31N5O2
• Target-Kategorie: AMPK,Apoptosis,MARK,Salt-inducible Kinase (SIK)

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound