Vofopitant (GR 205171A) is a blood-brain barrier-permeable NK1 receptor inhibitor with a pKi of 9.02 in mice. Vofopitant blocks vomiting-related responses and inhibits pseudoptyalism. Vofopitant exerts anxiolytic effects, regulates 5-HT receptor function and increases central 5-HT release. Vofopitant improves hyperarousal symptoms of post-traumatic stress disorder. Vofopitant can be used in research related to depression, anxiety, vomiting and postoperative nausea and vomiting[1][2][3][4][5][6].
Molekulargewicht:
432.44
Reinheit:
99.82
CAS Nummer:
[168266-90-8]
Formel:
C21H23F3N6O
Target-Kategorie:
Neurokinin Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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