K-8012, CAS [[1346513-17-4]]

Produktübersicht

• Artikelname: K-8012, CAS [[1346513-17-4]]
• Artikelnummer: MCE-HY-121435
• Hersteller Artikelnummer: HY-121435
• Alternativnummer: MCE-HY-121435-1MG, MCE-HY-121435-5MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

K-8012, a sulindac (HY-B0008) analog, is a potent antagonist of RXRa. The IC50 value for K-8012 to inhibit 9-cis-RA-induced Gal4-RXRa-LBD trans-activation were about 9.2 µM. K-8012 exerts improved anticancer activity over sulindac in a RXRa-dependent manner. K-8012 exhibits activity in inhibiting the tRXRa-mediated PI3K/AKT signaling pathway. K-8012 induces apoptosis and inhibits AKT activation by preventing tRXRa from binding to p85a[1].

Produkteigenschaften

• Molekulargewicht: 374.45
• Reinheit: 98.24
• CAS Nummer: [1346513-17-4]
• Formel: C23H23FN4
• Target-Kategorie: Akt,Apoptosis,PI3K,RAR/RXR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound