L-764406 is a non-thiazolidinedione (TZD)-type PPARg nuclear receptor ligand with high affinity. L-764406 has significant binding ability to PPARg (IC50=70 nM). L-764406 exhibited partial agonist activity and induced expression of the adipocyte-specific gene aP2 in chimeric receptors expressing the PPARg LBD and the corresponding reporter gene, as well as in 3T3-L1 cells. In contrast, L-764406 showed no activity in cells transfected with chimeric receptors containing PPARa or PPARd LBDs[1].
Molekulargewicht:
318.78
CAS Nummer:
[227002-04-2]
Formel:
C15H11ClN2O2S
Target-Kategorie:
PPAR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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