PS210 is a potent and selective PDK1 activator with a Kd of 3 µM and targets the PIF-binding pocket of PDK1. PS210 is inactive against other protein kinases, including PDK1 downstream signaling components such as S6K, PKB/Akt or GSK3. In cells, the prodrug of PS210 (PS423) acts as a substrate-selective inhibitor of PDK1, inhibiting the phosphorylation and activation of S6K[1][2].
Molekulargewicht:
380.31
Reinheit:
99.79
CAS Nummer:
[1221962-86-2]
Formel:
C19H15F3O5
Target-Kategorie:
PDK-1
Anwendungsbeschreibung:
MCE Product type: Reference compound
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