PU-20F (compound 59) is a Hsp90 inhibitor with an EC50 of 6.8 µM. PU-20F competes with Geldanamycin (HY-15230) for binding to Hsp90 and regulates the function of this molecular chaperone. PU-20F induces the degradation of oncogenic Her2 tyrosine kinase. PU-20F blocks the growth of breast cancer cells. PU-20F can be used in breast cancer-related research[1].
Molekulargewicht:
417.44
CAS Nummer:
[422508-29-0]
Formel:
C20H24FN5O4
Target-Kategorie:
HSP
Anwendungsbeschreibung:
MCE Product type: Reference compound
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