GW7845 is an orally active non-thiazolidinedione, tyrosine-derived PPARgamma agonist. GW7845 is effective at inhibiting voltage-dependent calcium channels (VDCC) and relaxing pressurized arteries with IC50 of 3 µM by using Ba2+ as the charge carrier through VDCC. GW7845-induced apoptosis is mitochondria- and apoptosome-dependent. GW7845 induces rapid mitochondrial membrane depolarization and release of cytochrome c in primary pro-B cells and BU-11 cells[1][2].
Molekulargewicht:
500.54
CAS Nummer:
[196809-22-0]
Formel:
C29H28N2O6
Target-Kategorie:
Apoptosis,Calcium Channel,PPAR
Anwendungsbeschreibung:
MCE Product type: Reference compound
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