ML309 is a highly selective and potent inhibitor of the R132H mutant isocitrate dehydrogenase 1 (IDH1 R132H), with an IC50 of 96 nM. ML309 is a competitive inhibitor of alpha-KG, with a Ki value of 156 nM, and its inhibitory activity against the wild-type IDH1 is greater than 35 µM. ML309 effectively reduces the production of the tumor metabolite 2-HG in U87MG cells. ML309 can be used as a chemical probe to study the role of the mutant IDH1 in cancer[1].
Molekulargewicht:
484.56
CAS Nummer:
[1355446-05-7]
Formel:
C29H29FN4O2
Target-Kategorie:
Isocitrate Dehydrogenase (IDH)
Anwendungsbeschreibung:
MCE Product type: Reference compound
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