Akuammine is an indole alkaloid that has been found in Picralima nitida and has analgesic activity. It selectively binds to the µ- and kappa-opioid receptors over the delta-opioid receptor (Kis=0.3, 1.68, and 10.4 µM for the human receptors, respectively). Akuammine inhibits forskolin-induced cAMP production in HEK293 cells expressing human µ- or kappa-opioid receptors (IC50s=2.6 and 0.073 µM, respectively). It increases the latency to withdrawal in the tail-flick or hot plate test in mice when administered at a dose of 60 mg/kg.
Molekulargewicht:
382.45
CAS Nummer:
[3512-87-6]
Formel:
C22H26N2O4
Target-Kategorie:
Others
Anwendungsbeschreibung:
MCE Product type: Reference compound
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