ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes beta-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 µM and 1.4 µM, respectively. ML339 shows weaker activity against the recruitment of beta-arrestin in mouse CXCR6 receptors, with an IC50 of 18 µM. ML339 has no inhibitory effect on CXCR5,CXCR4,CXCR6 and apelin receptor (APJ), with IC50 >79 µM. ML339 has the potential to promote the development of prostate cancer research[1][2].
Molekulargewicht:
502.00
Reinheit:
99.88
CAS Nummer:
[2579689-83-9]
Formel:
C26H32ClN3O5
Target-Kategorie:
Apelin Receptor (APJ),Arrestin,CXCR
Anwendungsbeschreibung:
MCE Product type: Reference compound
* Mehrwertsteuer und Versandkosten nicht enthalten. Irrtümer und Preisänderungen vorbehalten
