SW43 is a Sigma-2 selective ligand and agonist. SW43 is an ideal molecule for the development of cancer-targeted drug compounds. SW43 conjugated with DOX-L-NETA (89Y) exhibits antitumor activity in a VX2 cancer liver tumor allograft rabbit model. SW 43 conjugated with SW IV-52s to form SW III-123 activates the NF-kappaB pathway, has potent cytotoxicity against ovarian cancer cell lines, and induces apoptosis[1][2].
Molekulargewicht:
459.66
CAS Nummer:
[1590379-85-3]
Formel:
C27H45N3O3
Target-Kategorie:
Sigma Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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