Momordicine I is a cucurbitane-type triterpenoids. Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation. Momordicine I inhibits glycolysis, lipid metabolism, induces autophagy in HNC cells to suppress head and neck cancer growth. Momordicine I alleviates isoproterenol-induced cardiomyocyte hypertrophy through suppression of PLA2G6 and DGK-zeta. Momordicine I exerts its cardiovascular benefits by upregulating nitric oxide, inhibiting the activity of angiotensin-converting enzyme (ACE), activating the PI3K/Akt pathway, reducing oxidative stress and inflammation. Momordicine I inhibits AKT1, IL-6, and SRC, suggesting its potential application in type 2 diabetes[1][2][3][4][5].
Molekulargewicht:
472.70
Reinheit:
97
CAS Nummer:
[91590-76-0]
Formel:
C30H48O4
Target-Kategorie:
Akt,AMPK,Apoptosis,Autophagy,c-Met/HGFR,DGK,Endogenous Metabolite,Interleukin Related,Keap1-Nrf2,Mitochondrial Metabolism,mTOR,NF-kappaB,NO Synthase,Oxidative Phosphorylation,PI3K,Reactive Oxygen Species (ROS),Src,STAT
Anwendungsbeschreibung:
MCE Product type: Natural Products
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