MK-3697, CAS [[1224846-01-8]]

Produktübersicht

• Artikelname: MK-3697, CAS [[1224846-01-8]]
• Artikelnummer: MCE-HY-12301
• Hersteller Artikelnummer: HY-12301
• Alternativnummer: MCE-HY-12301-5MG,MCE-HY-12301-10MMX1ML,MCE-HY-12301-50MG,MCE-HY-12301-100MG,MCE-HY-12301-10MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

MK-3697 is an isonicotinamide small molecule, acting as a potent and selective Orexin 2 receptor antagonist with Ki = 0.95 nM. IC50 value: 0.95 nM(Ki) Target: Orexin 2 receptor antagonist MK-3697 is a highly potent, orally bioavailable selective orexin 2 receptor antagonists (2-SORAs) that possess acceptable profiles for clinical development. Herein we report additional SAR studies within the ''triaryl amide 2-SORA series focused on improvements in compound stability in acidic media and time-dependent inhibition of CYP3A4. MK-3697 has improved stability and TDI profiles as well as excellent sleep efficacy across species.

Produkteigenschaften

• Molekulargewicht: 447.51
• Reinheit: 98.83
• CAS Nummer: [1224846-01-8]
• Formel: C23H21N5O3S
• Target-Kategorie: Orexin Receptor (OX Receptor)

Anwendungsbeschreibung

• Anwendungsbeschreibung: Reference compound