Kenpaullone is a potent inhibitor of CDK1/cyclin B and GSK-3beta, with IC50s of 0.4 µM and 23 nM, and also inhibits CDK2/cyclin A, CDK2/cyclin E, and CDK5/p25 with IC50s of 0.68 µM, 7.5 µM, 0.85 µM, respectively. Kenpaullone, a small molecule inhibitor of KLF4, reduces self-renewal of breast cancer stem cells and cell motility in vitro.
Molekulargewicht:
327.18
Reinheit:
98.20
CAS Nummer:
[142273-20-9]
Formel:
C16H11BrN2O
Target-Kategorie:
CDK,GSK-3
Anwendungsbeschreibung:
Reference compound
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