c-di-AMP (Cyclic diadenylate) sodium is a STING agonist, which binds to the transmembrane protein STING thereby activating the TBK3-IRF3 signaling pathway, subsequently triggering the production of type I IFN and TNF. c-di-AMP sodium is also a bacterial second messenger, which regulates cell growth, survival, and virulence, primarily within Gram-positive bacteria, and also regulates host immune response. c-di-AMP sodium acts as a potent mucosal adjuvant stimulating both humoral and cellular responses[1][2][3][4].
Molekulargewicht:
702.38
Reinheit:
99.14
CAS Nummer:
[2734909-87-4]
Formel:
C20H22N10Na2O12P2
Target-Kategorie:
Bacterial,Endogenous Metabolite,STING
Anwendungsbeschreibung:
MCE Product type: Reference compound
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