COR628 is a positive allosteric modulator of GABA(B) receptors with the activity of enhancing GABA-induced GTPgammaS stimulation. COR628 showed significant activity in in vitro studies but did not exhibit endogenous agonist activity. COR628 has shown efficacy in experiments in mice by enhancing the sedation/hypnosis induced by baclofen, shortening the onset time and extending the duration of loss of righting reflex when combined with non-sedating doses of baclofen . The cytotoxic effect of COR628 is comparable to or higher than that of GS39783 or BHF177 in concentration[1].
Molekulargewicht:
309.42
CAS Nummer:
[550310-04-8]
Formel:
C16H23NO3S
Target-Kategorie:
GABA Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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