Nitroaspirin (NCX 4016) is a nitric oxide (NO) donor and a nitro-derivative of Aspirin, which combines with Nitroaspirin to inhibit cyclooxygenase. Nitroaspirin (NCX 4016) has antithrombotic and anti-platelet properties and acts as a direct and irreversible inhibitor of COX-1. Nitroaspirin (NCX 4016) causes significant induction of cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells via down-regulation of EGFR/PI3K/STAT3 signaling and modulation of Bcl-2 family proteins[1][2][3][4].
Molekulargewicht:
331.28
Reinheit:
98.57
CAS Nummer:
[175033-36-0]
Formel:
C16H13NO7
Target-Kategorie:
Apoptosis,COX
Anwendungsbeschreibung:
MCE Product type: Reference compound
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