LR1143 is a dopamine transporter (DAT) and 5-HT uptake inhibitor, with IC50 values of 3.4 nM and 112 nM in rats, respectively. LR1143 binds to DAT labeled with the dopamine reuptake inhibitor GBR 12935 (HY-12242A), with an IC50 of 4.4 nM. LR1143 shows lower selectivity for DAT than for serotonin reuptake sites. LR1143 can be used in studies related to cocaine abuse[1].
Molekulargewicht:
464.59
CAS Nummer:
[150151-15-8]
Formel:
C29H34F2N2O
Target-Kategorie:
5-HT Receptor,Dopamine Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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