C2 L-threo Ceramide (d18:1/2:0) (L-threo Cer(d18:1/2:0), L-threo Ceramide (d18:1/2:0)) is a bioactive sphingolipid and cell-permeable analog of naturally occurring ceramides. It stimulates cholesterol efflux in CHO cells expressing the human ABCA1 receptor when used at a concentration of 10 µM, however, this efflux is 50% less than that stimulated by C2 ceramide. C2 L-threo Ceramide inhibits IL-4 production by 17% in EL4 T cells stimulated with phorbol 12-myristate 13-acetate when used at a concentration of 10 µM. It also induces cell cycle arrest in the G0/G1 phase and a 7-fold increase in sphingosine accumulation as well as inhibits growth of HL-60 leukemia cells.
Molekulargewicht:
341.53
CAS Nummer:
[143615-69-4]
Formel:
C20H39NO3
Target-Kategorie:
Endogenous Metabolite
Anwendungsbeschreibung:
Reference compound
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