DBCO-NHCO-PEG4-amine is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. DBCO-NHCO-PEG4-amine is a cleavable ADC linker used to conjugate MMAE (HY-15162) and antibody (e.g., DBCO-VCpAB MMAE and DBCO-TRX MMAE with EC50s of 280 nM and 22 nM in SKBR3 cells, respectively)[1].
Molekulargewicht:
523.62
CAS Nummer:
[1255942-08-5]
Formel:
C29H37N3O6
Target-Kategorie:
ADC Linker,PROTAC Linkers
Anwendungsbeschreibung:
MCE Product type: ADC Related
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