AC-4-130 is a potent STAT5 SH2 domain inhibitor. AC-4-130 directly binds to STAT5 and disrupts STAT5 activation, dimerization, nuclear translocation, and STAT5-dependent gene transcription. AC-4-130 induces cell cycle arrest and apoptosis in FLT3-ITD-driven leukemic cells. AC-4-130 has anti-cancer activity and can efficiently block pathological levels of STAT5 activity in acute myeloid leukemia (AML)[1].
Molekulargewicht:
751.20
Reinheit:
99.93
CAS Nummer:
[1834571-82-2]
Formel:
C37H36ClF5N2O5S
Target-Kategorie:
Apoptosis,STAT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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