DI-591 is a potent, high-affinity and cell-permeable inhibitor of the DCN1-UBC12 interaction. DI-591 binds to DCN1 and DCN2 with Ki values of 12 nM and 10.4 nM, respectively and has no appreciable binding to DCN3, DCN4, and DCN5 proteins. DI-591 selectively inhibits neddylation of cullin 3 but has no or minimal effect on neddylation of other cullin family members[1].
Molekulargewicht:
585.80
Reinheit:
98.36
CAS Nummer:
[2245887-38-9]
Formel:
C31H47N5O4S
Target-Kategorie:
E1/E2/E3 Enzyme
Anwendungsbeschreibung:
Reference compound
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