NNC-0640, CAS [[307986-98-7]]

Produktübersicht

• Artikelname: NNC-0640, CAS [[307986-98-7]]
• Artikelnummer: MCE-HY-124622
• Hersteller Artikelnummer: HY-124622
• Alternativnummer: MCE-HY-124622-10MMX1ML,MCE-HY-124622-5MG,MCE-HY-124622-10MG,MCE-HY-124622-25MG,MCE-HY-124622-50MG,MCE-HY-124622-100MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien

Produktbeschreibung

NNC-0640 is an effective negative allosteric modulator (NAM) of the human glucagon receptor (GCGR), with an IC50 value of 69.2 nM. NNC-0640 binds to the external surface of the GCGR transmembrane domain, forms hydrogen bonds with residues S350, T353, and N404, and makes hydrophobic contacts with helices VI and VII. NNC-0640 stabilizes inactive GCGR conformation via a compact stalk and ECL1 beta-sheet structure that caps the orthosteric ligand-binding pocket. NNC-0640 can be used for the researches of type 2 diabetes[1][2].

Produkteigenschaften

• Molekulargewicht: 573.67
• Reinheit: 98.43
• CAS Nummer: [307986-98-7]
• Formel: C29H31N7O4S
• Target-Kategorie: GCGR

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound