PIK-C98 is a potent and selective PI3K inhibitor, with IC50s of 0.59, 1.64, 3.65, and 0.74 µM for alpha, beta, delta, and gamma isoforms, respectively. PIK-C98 inhibits all class I PI3Ks but has no effects on AKT or mTOR activity. PIK-C98 interferes with the ATP-binding pockets of PI3Ks by forming H-bonds and arene-H interactions with specific amino acid residues. PIK-C98 induces apoptosis by inhibiting PI3K. PIK-C98 can be used for the research of multiple myeloma[1].
Molekulargewicht:
349.23
CAS Nummer:
[691388-62-2]
Formel:
C16H10Cl2N2OS
Target-Kategorie:
Apoptosis,PI3K
Anwendungsbeschreibung:
MCE Product type: Reference compound
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