MN-25 (compound 4a) is an orally active indolpyridone that serves as a novel cannabinoid ligand. MN-25 has Ki of 245 nM and 11 nM for CB1 and CB2. MN-25 has CB2 agonist activity and inhibits TNF-R release in human peripheral blood mononuclear cells in vitro with an IC50 of 33 µM. MN-25 shows efficacy in a mouse acute inflammation model at oral doses up to 50 mg/kg>[1].
Molekulargewicht:
439.59
CAS Nummer:
[501926-82-5]
Formel:
C26H37N3O3
Target-Kategorie:
Cannabinoid Receptor,TNF Receptor
Anwendungsbeschreibung:
MCE Product type: Reference compound
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