AFM-30a hydrochloride is a potent protein arginine deiminase 2 (PAD2) inhibitor and has excellent PAD2-selectivity. AFM-30a hydrochloride binds to PAD2 with an EC50 value of 9.5 µM. AFM-30a hydrochloride also inhibits H3 citrullination with an EC50 value of 0.4 µM. AFM-30a hydrochloride can be used for the research of certain cancers and a variety of autoimmune diseases including rheumatoid arthritis (RA), multiple sclerosis, lupus, and ulcerative colitis[1].
Molekulargewicht:
502.97
Reinheit:
99.83
Formel:
C24H28ClFN6O3
Target-Kategorie:
Protein Arginine Deiminase
Anwendungsbeschreibung:
MCE Product type: Reference compound
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