MU1210 (compound 12f), a chemical probe, is an inhibitor of CDC-like kinases Clk1, Clk2, and Clk4 (with IC50 values of 8, 20, and 12 nM respectively), with IC50 for HIPK1 and DYRK2 are 187 and 1309 nM. MU1210 also has favorable pharmacokinetic characteristics (in mice, 10 mg/kg, intraperitoneal injection: Cmax=1.24 µM, T1/2=58 minutes, no acute toxicity observed)[1].
Molekulargewicht:
352.39
Reinheit:
99.50
CAS Nummer:
[2275601-87-9]
Formel:
C22H16N4O
Target-Kategorie:
CDK,DYRK
Anwendungsbeschreibung:
MCE Product type: Reference compound
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