PSB-1737 is a human-selective GPR17 agonist with an EC50 for human GPR17 of 270 nM, and its activity on murine GPR17 is relatively weak (EC50 > 10 µM). PSB-1737 shows no significant inhibition at the glycine binding site of NMDA receptors, and has no significant agonistic or antagonistic activity on P2Y receptor subtypes. PSB-1737 can be used in demyelinating diseases (such as multiple sclerosis) or inflammatory-related anemia[1].
Molekulargewicht:
325.32
CAS Nummer:
[139896-80-3]
Formel:
C18H15NO5
Target-Kategorie:
Orphan GPCR
Anwendungsbeschreibung:
MCE Product type: Reference compound1
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